Treatment of hayfever with loratadine a new non sedating antihistamine

There are many effective treatments available for AR; however, patients may be confused by product labeling.Pharmacists can inform and educate patients about available OTC products, point out differences in labeling, and help patients determine which medication is best for their needs.

PHARMACOLOGY OF ANTIHISTAMINES Antihistamines used to treat AR are competitive antagonists for histamine-1 (H Both first- and second-generation antihistamines alleviate AR symptoms or other upper respiratory allergies.Efficacy in AR Symptom Relief Results from clinical studies indicate that fexofenadine (Allegra) and cetirizine (Zyrtec) generally have a quicker onset of action in AR than loratadine (Claritin).Those given fexofenadine demonstrated statistically equivalent improvement in allergy symptoms as those given cetirizine.They are appropriate for use in the pediatric population, and 3 products, Allegra, Claritin, and Zyrtec, are FDA-approved as liquid formulations for use in children 2 years and older.Dosage information for OTC second-generation antihistamines is listed in the Table.

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