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The intercellular adhesion molecule-5 (ICAM-5), also known as telencephalin, is a membrane-spanning adhesion molecule that regulates neuronal development is several ways (Tian et al., 2000b, 2007; Matsuno et al., 2006; Gahmberg et al., 2014).ICAM-5 is expressed on the dendrites and soma of neurons of the telencephalon, with the highest level of expression in the glutamatergic neurons of the hippocampus and cerebral cortex.The α5β1 integrin [very late antigen-5, (VLA-5)] on neurons and the αLβ2 [leukocyte function associated antigen-1 (LFA-1)] on leukocytes have been demonstrated to act as receptors for ICAM-5 (Tian et al., 1997; Ning et al., 2013).Our laboratory has previously shown that ICAM-5 has an immunosuppressive effect on T cells (Tian et al., 2008).ICAM-5 further reduced the secretion of the proinflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β), but on the contrary induced the secretion of the anti-inflammatory IL-10 from lipopolysaccharide (LPS) stimulated microglia.

Louis, MO, United States, 00 in WB), mouse Ig G (Mi4 ms Ig G1, Merck Millipore, Burlington, MA, United States, 1 μg in IP), ICAM-1 function blocking antibody (LEAF purified rat Ig G2bκ, RTK4530, Bio Legend).The interaction with α-actinin is important for neurite sprouting and elongation and spine maturation (Nyman-Huttunen et al., 2006; Ning et al., 2015).Microglia express integrins that have been shown to bind ICAM-5 in other cells (Akiyama and Mc Geer, 1990).They can regulate synaptic plasticity, prune synaptic structures, provide neuronal guidance and secrete neurotrophic factors (Paolicelli et al., 2011; Hong et al., 2016).Microglia can make direct contact with both pre- and postsynaptic elements and modulate the collapse or maturation of synapses (Wake et al., 2009; Miyamoto et al., 2016).

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