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Epithelial ovarian cancer (EOC) is a deadly disease often detected after it has metastasized within the peritoneal cavity.
Multi-cellular spheroids are enriched in the ascites of EOC patients and they represent an invasive and chemoresistant cellular population fundamental to metastatic dissemination.
Dr, Ruch’s current research interests are to understand how gap junctions become defective in cancer cells and carcinogen-treated cells.
Assistant Professor University of California, Irvine, CA, 2007 Over 200,000 new cases of breast cancer are diagnosed in the U. each year, affecting 1 in 8 women in their life-time.
Despite the recent advances in diagnostic tools, breast cancer mortality rate has only declined slowly, justifying the urgent need for a better diagnostic marker for a treatment success.
These processes are mediated through an adaptor protein called LIM and SH3 Protein 1 (LASP-1) by ligand activated CXCR4.
The Raman lab has identified several key proteins that bind to nuclear LASP-1 in response to activation of CXCR4 by CXCL12 in breast cancer cells.